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CPE-008 · Testing
AI-05: ACTH-stimulation result
ACTH-stimulation result. Evaluates peak cortisol after 250 µg cosyntropin entered.
Active rulePriority 3Adrenal engine v1.0.0
Condition
- peak cortisol after 250 µg cosyntropin entered
What it reports
- Peak below 18 µg/dL (500 nmol/L): insufficient adrenal response
- Peak 18 µg/dL or above: adequate response, though recent-onset secondary insufficiency can still pass
Diagnostic boundary
- Assay cutoffs differ.
Evidence
- EV-ES-PAI-2016Bornstein SR, Allolio B, Arlt W, et al. Diagnosis and Treatment of Primary Adrenal Insufficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(2):364-389.Supports: Morning cortisol and ACTH as first tests; ACTH stimulation with 250 µg cosyntropin; peak cortisol below 18 µg/dL as insufficient Suspected adrenal crisis must be treated without waiting for tests
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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