Synthetic data only. Never enter patient information; nothing is sent or stored. For clinicians. Not FDA cleared.For licensed clinicians. Educational demonstration on synthetic data. Never enter real patient identifiers or protected health information: everything runs in your browser and nothing is sent or stored. Clinical decision support only; not FDA cleared; physician review is required.
CPE-008 · Classification
AI-07: Secondary or tertiary pattern
Secondary or tertiary pattern. Evaluates low cortisol.
Active rulePriority 3Adrenal engine v1.0.0
Condition
- low cortisol
- ACTH low or inappropriately normal (not raised)
Supportive, not required
- low DHEA-S for age
- other pituitary hormone deficiencies
- pituitary or hypothalamic disease, head trauma, surgery or radiation
What it reports
- Pattern of secondary (pituitary) or tertiary (hypothalamic or glucocorticoid-suppressed) adrenal insufficiency
Recommended next steps (for physician review)
- Assess the other pituitary axes and consider pituitary imaging
- Review exogenous glucocorticoid, opioid and megestrol exposure
Diagnostic boundary
- Exogenous glucocorticoid suppression produces the same pattern.
Evidence
- EV-ES-HYPOPIT-2016Fleseriu M, Hashim IA, Karavitaki N, et al. Hormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2016;101(11):3888-3921.Supports: Assess the adrenal axis before thyroid replacement in central hypothyroidism Secondary adrenal insufficiency testing
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
Try Biod in your practice
The Clinical Intelligence Layer — transforming fragmented clinical information into structured intelligence for clinician review and action.