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CPE-011 · Safety
AN-SAFE-03: Thrombotic microangiopathy pattern
Thrombotic microangiopathy pattern. Evaluates schistocytes on the film.
Active rulePriority 1Anemia engine v1.0.0
Condition
- schistocytes on the film
- platelets < 100 ×10³/µL
What it reports
- Urgent: pattern compatible with thrombotic microangiopathy (TTP, HUS, DIC)
Recommended next steps (for physician review)
- Urgent hematology evaluation, including ADAMTS13 testing
Diagnostic boundary
- Time-critical.
Evidence
- EV-ISTH-TTP-2020Zheng XL, Vesely SK, Cataland SR, et al. ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura. J Thromb Haemost. 2020;18(10):2486-2495.Supports: Schistocytes with thrombocytopenia: urgent evaluation including ADAMTS13
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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