Synthetic data only. Never enter patient information; nothing is sent or stored. For clinicians. Not FDA cleared.For licensed clinicians. Educational demonstration on synthetic data. Never enter real patient identifiers or protected health information: everything runs in your browser and nothing is sent or stored. Clinical decision support only; not FDA cleared; physician review is required.
CPE-007 · synthetic case CVR-FX-09
A PREVENT result is entered
The 2018 thresholds are not applied.
Purpose: The 2018 thresholds are not applied.
Inputs the engine received
Lipids and risk estimate
- LDL-C
- 130 mg/dL
- Total cholesterol
- 200 mg/dL
- HDL-C
- 50 mg/dL
- 10-year ASCVD risk (from your calculator)
- 6.2 %
- Calculator used
- PREVENT
Patient
- Age
- 58 years
What the engine reports
Detected clinical pattern
Risk Estimate Entered — No Category Assigned
The 2018 thresholds apply to the Pooled Cohort Equations; apply the thresholds that suit the tool used.
Calculations
- Non-HDL cholesterol
- 150 mg/dL
Total cholesterol minus HDL-C.
Evidence and rule trace · 2 rules
CV-04BRisk estimate from a tool the categories do not cover
Inputs: 10-year risk 6.2% (PREVENT)
No category assigned: the 2018 thresholds were set for the Pooled Cohort Equations.
Evidence
- EV-ACCAHA-CHOL-2018 · Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation. 2019;139(25):e1082-e1143.
- EV-PREVENT-2024 · Khan SS, Matsushita K, Sang Y, et al. Development and Validation of the American Heart Association's PREVENT Equations. Circulation. 2024;149(6):430-449.
Physician adjudication required. Clinical decision support for physician review. This output organizes guideline categories and risk modifiers. It does not calculate a 10-year risk, select a drug or dose, or replace a shared decision with the patient. Physician adjudication is required.
Change the values
The same engine, starting from this case. Change any value and watch the pattern and the rule trace react.
10-year risk category (Pooled Cohort Equations)
○ Low · <5%
Lifestyle emphasis
○ Borderline · 5 to <7.5%
Enhancers inform the discussion
○ Intermediate · 7.5 to <20%
Statin discussion favored; CAC can help
○ High · ≥20%
Statin benefit is greatest
No stage is assigned for the values entered.
Lipids and risk estimate
- <100
- 100–159
- 160–189
- ≥190
- <150
- 150–499
- ≥500
- ≥1000
This engine does not calculate it.
Patient
Recent ACS, prior MI, ischemic stroke, symptomatic PAD.
Age ≥65, HeFH, prior revascularization, diabetes, hypertension, CKD, smoking, HF.
Risk enhancers and extra tests
Treatment and familial risk
More cardio cases
CVR-FX-01
Prior myocardial infarction, LDL-C 88 on a statin
Secondary prevention, not very high risk.
CVR-FX-02
Very high risk with LDL-C 62 on maximal therapy
Two events: the threshold is 55.
CVR-FX-03
LDL-C 205 and tendon xanthomas
Severe hypercholesterolemia.
CVR-FX-04
Diabetes at 58 with LDL-C 110
A guideline statin group.
CVR-FX-05
Intermediate risk 12% with enhancers
Family history and an hs-CRP of 3.4.
CVR-FX-06
Borderline risk 6.0%, no enhancers
Nothing to push the decision either way.
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