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CPE-007 · Risk category
CV-02: Severe hypercholesterolemia
Severe hypercholesterolemia. Evaluates LDL-C ≥ 190 mg/dL.
Active rulePriority 2Cardio engine v1.0.0
Condition
- LDL-C ≥ 190 mg/dL
What it reports
- Severe hypercholesterolemia: the 2018 guideline supports statin therapy without a risk estimate in adults 20–75
Recommended next steps (for physician review)
- Exclude secondary causes before assuming a primary disorder
- Consider familial hypercholesterolemia
Diagnostic boundary
- Guideline statement; the decision is the physician's.
Evidence
- EV-ACCAHA-CHOL-2018Grundy SM, Stone NJ, Bailey AL, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol. Circulation. 2019;139(25):e1082-e1143.Supports: Risk categories, risk enhancers, statin benefit groups and the coronary-calcium decision aid Very-high-risk ASCVD definition
Cases where this rule fires
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