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CPE-004 · Calculations
ID-CALC-01: Derived values
Derived values. Evaluates serum iron and TIBC available → transferrin saturation.
Condition
- serum iron and TIBC available → transferrin saturation
- MCV and RBC count available → Mentzer index
What it reports
- Transferrin saturation = serum iron ÷ TIBC × 100
- Mentzer index = MCV ÷ RBC count (10¹²/L)
Diagnostic boundary
- Informational calculations.
Evidence
- EV-MENTZER-1973Mentzer WC Jr. Differentiation of iron deficiency from thalassaemia trait. Lancet. 1973;1(7808):882.Supports: MCV ÷ RBC count below 13 favors thalassemia trait; above 13 favors iron deficiency
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
IRON-FX-01
Classic iron-deficiency anemia in a premenopausal woman
A 34-year-old with heavy periods, Hb 9.8, MCV 72 and a ferritin of 6.
IRON-FX-03
Iron-deficiency anemia in a man
A 61-year-old man with Hb 10.9, MCV 76 and a ferritin of 9.
IRON-FX-05
Rheumatoid arthritis: ferritin 85, TSAT 12
Hb 10.4 with a ferritin that looks normal and a CRP of 18.
IRON-FX-06
Inflammation with ferritin 48 and TSAT 9
Ferritin looks near normal but sits under the WHO inflammation cutoff of 70.
IRON-FX-07
Microcytic anemia with preserved iron indices
MCV 62, RBC 5.6, ferritin 95 and TSAT 28.
IRON-FX-08
Heart failure with ferritin 82
A 70-year-old man with heart failure and a normal hemoglobin.
IRON-FX-09
Heart failure with ferritin 180 and TSAT 14
Ferritin 100–299 with low saturation meets the heart-failure definition.
IRON-FX-11
Anemia in chronic kidney disease
Hb 10.2, ferritin 140 and TSAT 17 in CKD.
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