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CPE-003 · synthetic case CKD-EX-10
UACR doubled between measurements
UACR 120 to 260 mg/g in confirmed CKD.
Purpose: UACR 120 to 260 mg/g in confirmed CKD.
Inputs the engine received
Patient
- Age
- 60 years
Context
- Sex for equation
- female
- CKD confirmed
- Yes
- G category
- G3a
Laboratory
- UACR series
- 120 mg/g (2025-09-01, first morning void) → 260 mg/g (2026-03-10, first morning void)
What the engine reports
Detected clinical pattern
Criteria for CKD Met — Classified
Chronicity is documented and the result is classified CKD G3aA2. This is criteria-based status, not a probability.
- Chronicity: Chronicity confirmed (≥3 months)
- CGA: CKD G3aA2
Clinical summary
CKD G3aA2: criteria met on documented chronicity (UACR 260 mg/g). Priority: complete risk stratification, review etiology and kidney-protective management.
Why this pattern was identified
- Albuminuria. UACR 260 mg/g, category A2 (30–300 mg/g).
- Persistence. Abnormal results are dated at least three months apart.
- CKD criteria met. CKD G3aA2 on documented chronicity. Criteria-based status, not a probability.
Recommended next steps
For physician consideration. Urgent review always comes first.
- 1Confirm complete risk stratification (CGA) and review etiology, blood pressure and kidney-protective management.
- 2Monitor eGFR and UACR longitudinally at an interval set by the CGA risk category.
Missing information
- Cystatin C (optional; improves GFR accuracy near decision thresholds).
- Urine sediment / microscopy (supports etiologic adjudication).
Why it matters
CKD with albuminuria and reduced GFR is associated with higher risks of kidney progression and cardiovascular disease, and the CGA category sets monitoring intensity.
Abnormal results are present on dated measurements separated by at least three months, supporting chronicity. Progression signal: uACR doubling.
Evidence and rule trace · 6 rules
DET-001Kidney abnormality detected
Inputs: UACR 260 mg/g (≥30)
kidney_abnormality_detected: determine chronicity and evaluate acute causes before confirming CKD
CHR-001CKD chronicity confirmed through longitudinal evidence
Inputs: UACR ≥30 on 2 dated results spanning 190 days
chronicity_status: confirmed
CGA-001Assign G category from selected indexed eGFR
Inputs: G category G3a (documented)
G3a (45–59 mL/min/1.73 m²)
PROG-003UACR doubling
Inputs: UACR 120 → 260 mg/g
uACR_doubling: exceeds expected laboratory variability and warrants evaluation
Evidence
- R1 · KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Disease: Improving Global Outcomes (KDIGO), 2024.
Physician adjudication required. Clinical decision support for physician review. Criteria-based status is not a probability. Findings require physician adjudication and correlation with the complete clinical context. Validation-only release: not for production clinical use.
Change the values
The same engine, starting from this case. Change any value and watch the pattern and the rule trace react.
Live eGFR and CGA map
eGFR (mL/min/1.73 m²)
—
enter a creatinine
| GFR \ ALB | A1<30 | A230–300 | A3>300 |
|---|---|---|---|
| G1≥90 | |||
| G260–89 | |||
| G3a45–59 | ● | ||
| G3b30–44 | |||
| G415–29 | |||
| G5<15 |
Classified: CKD G3aA2. Colors follow the KDIGO risk heat map: green low, yellow moderately increased, orange high, red very high.
Kidney functionAdd a prior result with dates to test chronicity
Switches the engine to the combined eGFRcr-cys equation.
Albuminuria
Chemistry
Kidney findings and red flags
Context
Transient albuminuria confounders
Creatinine may be unreliable
Complications (persistent)
Therapy
Documented history and special populations
This case also carries values that have no field here: G_category. They are included in the calculation until you clear the form.
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CKD-FX-003
Single reduced eGFR without chronicity
Single reduced eGFR without chronicity
CKD-FX-004
Acute creatinine rise before CKD staging
Acute creatinine rise before CKD staging
CKD-FX-005
Isolated suspected G3a requiring cystatin C confirmation support
Isolated suspected G3a requiring cystatin C confirmation support
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Combined eGFR reclassification support
Combined eGFR reclassification support
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