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CPE-005 · synthetic case LIVER-FX-16
ALT 1,350 U/L
Values far above anything MASLD explains.
Purpose: Values far above anything MASLD explains.
Inputs the engine received
Liver tests and imaging
- Hepatic steatosis documented
- Yes
- AST
- 980 U/L
- ALT
- 1350 U/L
- Platelets
- 215 ×10⁹/L
Patient
- Age
- 50 years
- Sex
- Female
- Alcohol intake
- 0 g/day
Cardiometabolic criteria
- BMI
- 29 kg/m²
Other liver disease and context
- Hepatitis B and C testing already done
- Yes
What the engine reports
Values this high are not typical of MASLD: acute hepatitis (viral, drug, ischemic, autoimmune) needs to be considered.
A high-risk non-invasive result (or known cirrhosis) needs specialist evaluation. Confirmation of stage belongs to hepatology.
Detected clinical pattern
Urgent Review Finding
A safety rule calls for urgent clinical assessment. Read the safety findings first.
- Alcohol: Alcohol 0 g/day · MASLD range
- Fibrosis risk: Fibrosis risk · high
- Pattern: masld criteria met
Why this pattern was identified
- MASLD criteria. Steatosis is documented and 1 cardiometabolic criterion/criteria are met (BMI 29).
Calculations
- FIB-4
- 6.2
Lower cutoff 1.3; high above 2.67.
Recommended next steps
For physician consideration. Urgent review always comes first.
- 1Evaluate for acute hepatitis and other causes of marked aminotransferase elevation.
- 2Consider referral to hepatology.AASLD 2023.
- 3Assess cardiovascular risk: it is the leading cause of death in MASLD.
Evidence and rule trace · 9 rules
LV-01MASLD criteria met
Inputs: steatosis documented · 1 cardiometabolic criterion/criteria: BMI 29 · alcohol in MASLD range
Pattern meeting the 2023 MASLD criteria.
LV-CV-01Cardiovascular risk assessment
Inputs: MASLD criteria met
Formal cardiovascular risk assessment is part of the work-up.
LV-04ALT above the AASLD upper limit
Inputs: ALT 1350 U/L (limit 25 for female)
ALT above the sex-specific upper limit.
LV-REF-01Hepatology referral to consider
Inputs: advanced fibrosis likely
Referral to hepatology is reasonable to consider.
LV-SAFE-02Marked aminotransferase elevation
Inputs: peak aminotransferase 1350 U/L
Values this high are not typical of MASLD.
Evidence
- EV-AASLD-2023 · Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-1835.
- EV-DELPHI-2023 · Rinella ME, Lazarus JV, Ratziu V, et al. A multisociety Delphi consensus statement on new fatty liver disease nomenclature. Hepatology. 2023;78(6):1966-1986.
- EV-MCPHERSON-2017 · McPherson S, Hardy T, Dufour JF, et al. Age as a confounding factor for the accurate non-invasive diagnosis of advanced NAFLD fibrosis. Am J Gastroenterol. 2017;112(5):740-751.
Physician adjudication required. Clinical decision support for physician review. This output classifies steatotic liver disease under the 2023 nomenclature and stratifies fibrosis risk. It does not stage fibrosis by itself, diagnose a cause, or recommend a drug. Physician adjudication is required.
Change the values
The same engine, starting from this case. Change any value and watch the pattern and the rule trace react.
Fibrosis risk by non-invasive tests
✓ Low
FIB-4 <1.3 (<2.0 from 65), stiffness <8 kPa
✓ Indeterminate
Needs a second-line test
● High
FIB-4 >2.67, stiffness ≥12 kPa or ELF ≥9.8
Liver tests and imaging
Patient
A standard US drink is about 14 g.
Cardiometabolic criteria
Other liver disease and context
Cirrhosis, decompensation and trends
More liver cases
LIVER-FX-01
Steatosis with metabolic risk and a low FIB-4
A 52-year-old man with fatty liver on ultrasound, BMI 31 and triglycerides 190.
LIVER-FX-02
Type 2 diabetes, no imaging yet
A 58-year-old with diabetes and normal enzymes: the screening question.
LIVER-FX-03
Indeterminate FIB-4
FIB-4 of 2.0 in a 56-year-old with steatosis.
LIVER-FX-04
High FIB-4
FIB-4 above 5 in a 63-year-old man with low platelets.
LIVER-FX-05
FIB-4 of 1.65 at age 70
Low risk under the age-adjusted cutoff of 2.0.
LIVER-FX-06
Stiffness 14 kPa with a low FIB-4
Discordant tests: the elastography result prevails as a warning.
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