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CPE-005 · Safety
LV-SAFE-03: Synthetic dysfunction or marked cholestasis
Synthetic dysfunction or marked cholestasis. Evaluates total bilirubin above 3 mg/dL OR INR above 1.5 OR albumin below 3.0 g/dL.
Condition
- total bilirubin > 3 mg/dL OR INR > 1.5 OR albumin < 3.0 g/dL
What it reports
- Priority review: markers of impaired liver function
Diagnostic boundary
- Do not attribute to MASLD without excluding other causes.
Evidence
- EV-AASLD-2023Rinella ME, Neuschwander-Tetri BA, Siddiqui MS, et al. AASLD Practice Guidance on the clinical assessment and management of nonalcoholic fatty liver disease. Hepatology. 2023;77(5):1797-1835.Supports: FIB-4 first for risk stratification; thresholds <1.3 and >2.67; elastography 8 and 12 kPa; ELF 7.7 and 9.8 ALT upper limits near 29–33 U/L (men) and 19–25 U/L (women) Cardiovascular risk is the leading cause of death in MASLD
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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