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CPE-001 · synthetic case FX-011
LDL and CK pattern without thyroid labs
No thyroid tests yet, but LDL 168 and CK 285 on a statin.
Purpose: Use metabolic/muscular findings as screening trigger only.
Inputs the engine received
Patient
- Age and sex
- 58, female
Medications
- Statin
- Yes
Symptoms
- Fatigue
- Present
- Constipation
- Present
- Hair loss
- Present
Laboratory
- LDL-C
- 168 mg/dL (ref 0–100)
- CK
- 285 U/L (ref 30–170)
What the engine reports
Detected clinical pattern
Thyroid Evaluation Screening Trigger Identified
Associated clinical or laboratory findings justify consideration of thyroid-function testing; this is not a diagnosis.
Why this pattern was identified
- Screening trigger. LDL-C 168 mg/dL (ref 0–100) with compatible context
- Screening trigger. CK 285 U/L (ref 30–170) with myopathy or statin context
- Screening trigger. 3 compatible symptoms without a recent TSH
Recommended next steps
For physician consideration. Urgent review always comes first.
- 1Consider ordering TSH and FT4; evaluate Anti-TPO only after biochemical/context review when etiology matters.
Differentials, pitfalls and contradicting signals
- Other causes of the same findings (statin effect, exercise, renal, hepatic or metabolic disease).
Missing information
- TSH and FT4 with laboratory reference ranges (required for functional thyroid-state classification).
Evidence and rule trace · 1 rules
PR-HT-04Secondary-Cause Screening Trigger from Metabolic or Muscular Findings
Inputs: LDL-C 168 mg/dL (ref 0–100) with compatible context · CK 285 U/L (ref 30–170) with myopathy or statin context · 3 compatible symptoms without a recent TSH
Consider thyroid-function testing. Not a diagnosis.
Physician adjudication required. For clinician review only. This output identifies clinical patterns and safety considerations from the documented inputs. It does not establish an autonomous diagnosis or treatment plan. Physician confirmation is required.
Change the values
The same engine, starting from this case. Change any value and watch the pattern and the rule trace react.
Thyroid-function testsMove the sliders or type values
- below range
- within range
- above range
- below range
- within range
- above range
Zones are drawn from your reference intervals. The engine, not the map, decides the pattern.
Laboratory values and reference rangesUse your lab's own interval
µIU/mL and mIU/L are numerically identical.
Interpreted against the reporting assay's upper limit.
Only used in the thyrotoxicosis pathway.
Patient context
Medications and exposures
Symptoms and physical findingsSupportive only: never classify on their own
Symptoms
Signs and decompensation red flags
More thyroid cases
FX-001
Overt primary hypothyroidism with autoimmune support
A 54-year-old with fatigue, cold intolerance and a TSH of 18.4.
FX-002
Antibody positive with euthyroid function
Strongly positive antibodies, but TSH and FT4 are both normal.
FX-003
Mild subclinical pattern with positive Anti-TPO
Mildly high TSH, normal FT4, positive Anti-TPO.
FX-004
TSH at or above 10 with normal FT4
TSH of 12 with a normal FT4 in a woman of 57.
FX-005
Pregnancy context with mild TSH elevation and Anti-TPO positivity
Pregnant, TSH 3.1 against a pregnancy range, Anti-TPO positive.
FX-006
Preconception infertility context
Trying to conceive, TSH 4.8, Anti-TPO positive.
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