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CPE-004 · Iron overload
ID-OV-01: Iron-overload pattern
Iron-overload pattern. Evaluates transferrin saturation above 45%.
Active rulePriority 3Iron engine v1.0.0
Condition
- transferrin saturation > 45%
- ferritin > 300 ng/mL (men) or > 200 ng/mL (women)
What it reports
- Pattern that raises the possibility of iron overload
Recommended next steps (for physician review)
- Repeat on a fasting morning sample
- Physician to consider HFE genotyping per EASL 2022
- Consider liver, diabetes and heart involvement
Diagnostic boundary
- Not a diagnosis of hemochromatosis.
Evidence
- EV-EASL-HFE-2022European Association for the Study of the Liver. EASL Clinical Practice Guidelines on haemochromatosis. J Hepatol. 2022;77(2):479-502.Supports: Transferrin saturation >45% as the first-line screen Ferritin above 200 µg/L (women) or 300 µg/L (men) with raised saturation prompts HFE testing
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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