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CPE-004 · Iron overload
ID-OV-02: Very high ferritin
Very high ferritin. Evaluates ferritin above 1000 ng/mL.
Active rulePriority 2Iron engine v1.0.0
Condition
- ferritin > 1000 ng/mL
What it reports
- Priority review: very high ferritin has several serious causes
Recommended next steps (for physician review)
- Consider iron overload, hepatocellular injury, hemolysis, malignancy, macrophage activation and inflammation
Diagnostic boundary
- Ferritin alone does not identify the cause.
Evidence
- EV-EASL-HFE-2022European Association for the Study of the Liver. EASL Clinical Practice Guidelines on haemochromatosis. J Hepatol. 2022;77(2):479-502.Supports: Transferrin saturation >45% as the first-line screen Ferritin above 200 µg/L (women) or 300 µg/L (men) with raised saturation prompts HFE testing
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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