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CPE-003 · GFR estimation
GFR-004: Creatinine reliability limitation
Creatinine reliability limitation. Evaluates low muscle mass is true.
Active rulePriority 53Kidney engine v1.2.0
Condition
- Any of:
- low muscle mass == true
- amputation == true
- bodybuilder or extreme exercise == true
- creatine supplement use == true
- cirrhosis == true
- heart failure == true
- malnutrition == true
- cancer or catabolic state == true
- medication affecting creatinine secretion == true
What it reports
- Warning: Non-GFR determinant may distort creatinine-based eGFR. Consider eGFRcr-cys or measured GFR according to clinical decision importance.
Evidence
- R1KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Disease: Improving Global Outcomes (KDIGO), 2024.Supports: CKD definition and chronicity CGA classification albuminuria confirmation risk prediction referral medication stewardship progression monitoring
- R3eGFR Equations for Adults: 2021 CKD-EPI creatinine and creatinine-cystatin C race-free equations. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) / NIH, 2026.Supports: eGFRcr computation eGFRcr-cys computation assay standardization adult eligibility
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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