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CPE-005 · Context triggers
LV-HFE-01: Iron-overload pattern
Iron-overload pattern. Evaluates transferrin saturation above 45%.
Active rulePriority 3Liver engine v1.0.0
Condition
- transferrin saturation > 45%
- ferritin > 300 ng/mL (men) or > 200 ng/mL (women)
What it reports
- Possible iron overload: hemochromatosis testing may be appropriate
Diagnostic boundary
- Hyperferritinemia is common in MASLD; high saturation is what makes this pattern.
Evidence
- EV-EASL-HFE-2022European Association for the Study of the Liver. EASL Clinical Practice Guidelines on haemochromatosis. J Hepatol. 2022;77(2):479-502.Supports: Transferrin saturation >45% with raised ferritin prompts HFE testing
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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