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CPE-010 · Exclusions
PC-09: Non-classic congenital adrenal hyperplasia possible
Non-classic congenital adrenal hyperplasia possible. Evaluates early-follicular-phase morning 17-hydroxyprogesterone ≥ 200 ng/dL.
Condition
- early-follicular-phase morning 17-hydroxyprogesterone ≥ 200 ng/dL
What it reports
- A raised 17-hydroxyprogesterone raises non-classic congenital adrenal hyperplasia
Recommended next steps (for physician review)
- Consider an ACTH-stimulation test to confirm or exclude non-classic CAH
Diagnostic boundary
- Not a diagnosis; confirmation needs stimulation testing.
Evidence
- EV-ES-HIRSUTISM-2018Martin KA, Anderson RR, Chang RJ, et al. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(4):1233-1257.Supports: Hirsutism assessment (modified Ferriman–Gallwey), biochemical evaluation, and markedly raised androgens or rapid onset as tumor signals
- EV-ES-NCCAH-2018Speiser PW, Arlt W, Auchus RJ, et al. Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(11):4043-4088.Supports: Early-follicular-phase morning 17-hydroxyprogesterone as the screen for non-classic CAH, confirmed by ACTH stimulation
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