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CPE-010 · Safety
PC-SAFE-01: Possible androgen-secreting tumor
Possible androgen-secreting tumor. Evaluates total testosterone above 150 ng/dL OR DHEA-S above 700 µg/dL OR rapid-onset severe hirsutism or virilization (clitoromegaly, voice deepening).
Condition
- total testosterone > 150 ng/dL OR DHEA-S > 700 µg/dL OR rapid-onset severe hirsutism or virilization (clitoromegaly, voice deepening)
What it reports
- Urgent evaluation: values or features this marked are not explained by PCOS
Recommended next steps (for physician review)
- Urgent evaluation, including imaging of the adrenals and ovaries per physician judgment
Diagnostic boundary
- PCOS is a diagnosis of exclusion; do not assign it until a tumor is excluded.
Evidence
- EV-ES-HIRSUTISM-2018Martin KA, Anderson RR, Chang RJ, et al. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(4):1233-1257.Supports: Hirsutism assessment (modified Ferriman–Gallwey), biochemical evaluation, and markedly raised androgens or rapid onset as tumor signals
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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