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CPE-001 · Functional-state patterns
PR-HT-02: Possible Subclinical Hypothyroidism Pattern
Possible Subclinical Hypothyroidism Pattern. Biochemical pattern requiring context. Requires TSH above laboratory upper reference limit.
Required to fire
- TSH > laboratory upper reference limit
- FT4 within laboratory reference range
What it reports
- Functional state: possible subclinical hypothyroidism pattern
Recommended next steps (for physician review)
- Confirm persistence with repeat TSH and FT4 when clinically appropriate before long-term therapy decisions.
- Review symptoms, age, TSH magnitude/persistence, Anti_TPO status, cardiovascular context, goiter and special-population routing.
- If pregnant or attempting conception/fertility treatment, apply dedicated context module.
Never outputs
- Automatic treatment
- Overt hypothyroidism
Evidence
- EV-AACE-ATA-2012Garber JR et al. Clinical Practice Guidelines for Hypothyroidism in Adults. Endocr Pract. 2012;18(6):988-1028.Supports: Subclinical hypothyroidism below TSH 10 requires individualized treatment decision.
- EV-ATA-PREGAmerican Thyroid Association. Hypothyroidism in Pregnancy; based on ATA pregnancy guidance.Supports: TPO-positive pregnancy: treat when TSH above 4.0; consider treatment at 2.5-4.0; special-population routing.
- EV-ASRM-2024ASRM Practice Committee. Subclinical hypothyroidism in the infertile female population: a guideline. Fertil Steril. 2024;121:765-782.Supports: Fertility-specific uncertainty and avoidance of blanket treatment logic.
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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