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CPE-001 · Functional-state patterns
PR-HT-05: Thyrotoxicosis with Autoimmune Marker - Etiology Not Yet Classified
Thyrotoxicosis with Autoimmune Marker - Etiology Not Yet Classified. Differential required. Requires TSH below laboratory lower reference limit or suppressed.
Required to fire
- TSH below laboratory lower reference limit or suppressed
- FT4 above laboratory upper reference limit or T3 elevated
Supportive, not required
- Anti TPO positive
- Anti TG positive
What it reports
- Functional state: thyrotoxicosis pattern
- Safety alert: thyrotoxicosis requires etiologic differentiation
Recommended next steps (for physician review)
- Evaluate Graves disease versus destructive thyroiditis using clinical context and TRAb/TSI when appropriate.
- Consider imaging or uptake assessment only when clinically appropriate and not contraindicated by pregnancy or lactation.
Never outputs
- Hashitoxicosis confirmed from Anti TPO alone
- Automatic antithyroid therapy recommendation
Evidence
- EV-ATA-THYROIDITISAmerican Thyroid Association. Thyroiditis.Supports: Destructive/postpartum thyroiditis can have thyrotoxic then hypothyroid phases; etiologic differentiation needed.
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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