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Synthetic data only. Never enter patient information; nothing is sent or stored. For clinicians. Not FDA cleared.

CPE-010 · synthetic case PCOS-FX-02

Irregular cycles and polycystic ovaries

No hyperandrogenism, 22 follicles per ovary.

Synthetic · no real patientAuthored by Biod · reviewed by Dr. AmaralPCOS engine v1.0.0

Purpose: No hyperandrogenism, 22 follicles per ovary.

Inputs the engine received

Cycles and clinical signs

Age
29 years
Years since menarche
16 years
Cycles per year
7

Laboratory and imaging

TSH
1.8 mIU/L
Prolactin
12 ng/mL
17-hydroxyprogesterone (early follicular, morning)
60 ng/dL
Follicles per ovary (largest)
22

Cardiometabolic, sleep, mood and fertility

BMI
24 kg/m²
Months since last glycemic assessment
6 months
Depression and anxiety screening done
Yes

What the engine reports

Detected clinical pattern

Pattern Meeting the 2023 PCOS Criteria

Criteria are met and other causes are excluded. A pattern for physician review; the work-up of cardiometabolic risk, sleep, mood and fertility follows.

  • Criteria met: 2 of 3 criteria

Why this pattern was identified

  • Criteria. 2 of 3 criteria are met (irregular cycles; polycystic morphology or raised AMH), and other causes have been excluded.

Recommended next steps

For physician consideration. Urgent review always comes first.

  1. 1Assess BMI and waist, blood pressure and a lipid profile; the metabolic engine applies the metabolic-syndrome criteria.

Differentials, pitfalls and contradicting signals

  • A normal BMI does not exclude insulin resistance or other metabolic risk in PCOS.

Missing information

  • Total testosterone with SHBG (high-quality assay).
Evidence and rule trace · 6 rules

PC-02Criterion: irregular cycles

Inputs: 7 cycles a year

Irregular cycles / ovulatory dysfunction.

PC-04Criterion: polycystic ovarian morphology or raised AMH

Inputs: 22 follicles

Polycystic ovarian morphology or raised AMH.

PC-05PCOS criteria met

Inputs: 2 of 3 criteria · exclusions completed

Pattern meeting the 2023 international PCOS criteria.

PC-MISS-01Information needed

Inputs: work-up incomplete

The tests needed to complete criteria and exclusions are not all entered.

PC-13Cardiometabolic assessment

Inputs: PCOS criteria met

Cardiometabolic assessment.

PC-14Normal weight does not exclude metabolic risk

Inputs: BMI 24

Normal weight does not exclude metabolic risk.

Evidence

  • EV-PCOS-2023 · Teede HJ, Tay CT, Laven JJE, et al. Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2023;108(10):2447-2469.
  • EV-ROTTERDAM-2004 · Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-47.

Physician adjudication required. Clinical decision support for physician review. This output applies published criteria to the values entered. It does not diagnose, exclude other causes by itself, or choose contraception, ovulation induction or any treatment. Physician adjudication is required.

Change the values

The same engine, starting from this case. Change any value and watch the pattern and the rule trace react.

Criteria met (adults need 2 of 3)

  1. ✓ 0 of 3

    No criterion met

  2. ✓ 1 of 3

    Not enough

  3. ● 2 of 3

    Criteria met if causes are excluded

  4. ○ 3 of 3

    All three present

Cycles and clinical signs

6 or more (4 or more in some ethnicities).

Laboratory and imaging

25 ng/mL is assumed when empty.

Endovaginal ultrasound. Not used in adolescents.

Cardiometabolic, sleep, mood and fertility

Live result · computed in your browser

Detected clinical pattern

Pattern Meeting the 2023 PCOS Criteria

Criteria are met and other causes are excluded. A pattern for physician review; the work-up of cardiometabolic risk, sleep, mood and fertility follows.

  • Criteria met: 2 of 3 criteria

Why this pattern was identified

  • Criteria. 2 of 3 criteria are met (irregular cycles; polycystic morphology or raised AMH), and other causes have been excluded.

Recommended next steps

For physician consideration. Urgent review always comes first.

  1. 1Assess BMI and waist, blood pressure and a lipid profile; the metabolic engine applies the metabolic-syndrome criteria.

Differentials, pitfalls and contradicting signals

  • A normal BMI does not exclude insulin resistance or other metabolic risk in PCOS.

Missing information

  • Total testosterone with SHBG (high-quality assay).
Evidence and rule trace · 6 rules

PC-02Criterion: irregular cycles

Inputs: 7 cycles a year

Irregular cycles / ovulatory dysfunction.

PC-04Criterion: polycystic ovarian morphology or raised AMH

Inputs: 22 follicles

Polycystic ovarian morphology or raised AMH.

PC-05PCOS criteria met

Inputs: 2 of 3 criteria · exclusions completed

Pattern meeting the 2023 international PCOS criteria.

PC-MISS-01Information needed

Inputs: work-up incomplete

The tests needed to complete criteria and exclusions are not all entered.

PC-13Cardiometabolic assessment

Inputs: PCOS criteria met

Cardiometabolic assessment.

PC-14Normal weight does not exclude metabolic risk

Inputs: BMI 24

Normal weight does not exclude metabolic risk.

Evidence

  • EV-PCOS-2023 · Teede HJ, Tay CT, Laven JJE, et al. Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2023;108(10):2447-2469.
  • EV-ROTTERDAM-2004 · Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-47.

Physician adjudication required. Clinical decision support for physician review. This output applies published criteria to the values entered. It does not diagnose, exclude other causes by itself, or choose contraception, ovulation induction or any treatment. Physician adjudication is required.

More pcos cases

PCOS-FX-01

Irregular cycles and hirsutism, exclusions complete

A 26-year-old with 8 cycles a year and an mFG of 9.

PCOS-FX-03

Hyperandrogenism and polycystic ovaries with regular cycles

Ovulatory phenotype.

PCOS-FX-04

Irregular cycles only

One criterion is not enough.

PCOS-FX-05

Criteria met, no exclusion tests

TSH, prolactin and 17-OHP missing.

PCOS-FX-06

Prolactin 68 ng/mL

Another cause of oligomenorrhea.

PCOS-FX-07

TSH 9.2 mIU/L

Thyroid disease explains irregular cycles.

All pcos cases

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