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CPE-004 · Iron status
ID-ST-05: Inflammation-associated iron restriction possible
Inflammation-associated iron restriction possible. Evaluates inflammation documented or hs-CRP above 5 mg/L.
Condition
- inflammation documented or hs-CRP above 5 mg/L
- ferritin 70 to 299 ng/mL
- transferrin saturation < 20%
What it reports
- Functional iron restriction possible: anemia of inflammation, with or without absolute deficiency
Diagnostic boundary
- Cannot separate anemia of inflammation from combined deficiency by these values alone.
Evidence
- EV-CAMASCHELLA-2015Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19):1832-1843.Supports: Stages of iron deficiency, causes and differential diagnosis of microcytic anemia
- EV-AHA-HF-2022Heidenreich PA, Bozkurt B, Aguilar D, et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure. Circulation. 2022;145(18):e895-e1032.Supports: Iron deficiency in heart failure: ferritin <100 ng/mL, or 100–299 ng/mL with transferrin saturation <20%
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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