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CPE-004 · Iron status

ID-ST-01: Iron stores depleted (ferritin below 15)

Iron stores depleted (ferritin below 15). Evaluates ferritin below 15 ng/mL.

Active rulePriority 4Iron engine v1.0.0

Condition

  • ferritin < 15 ng/mL
  • no inflammation or CRP elevation changing the cutoff

What it reports

  • Iron stores depleted: absolute iron deficiency criterion met (WHO)

Recommended next steps (for physician review)

  • Look for the cause: blood loss, diet, absorption and increased demand
  • Complete iron studies and a CBC if not recent

Diagnostic boundary

  • A criterion for iron deficiency, not a statement about its cause.

Evidence

  • EV-WHO-FERR-2020World Health Organization. WHO guideline on use of ferritin concentrations to assess iron status in individuals and populations. Geneva: WHO; 2020.Supports: Ferritin below 15 µg/L indicates iron deficiency in healthy adults A higher cutoff (<70 µg/L) applies in the presence of infection or inflammation
  • EV-CAMASCHELLA-2015Camaschella C. Iron-deficiency anemia. N Engl J Med. 2015;372(19):1832-1843.Supports: Stages of iron deficiency, causes and differential diagnosis of microcytic anemia

Cases where this rule fires

Open a case to see this rule fire with real inputs, then change the values until it stops.

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