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CPE-011 · Etiologic patterns
AN-12: Thalassemia-trait pattern
Thalassemia-trait pattern. Evaluates anemia present.
Active rulePriority 4Anemia engine v1.0.0
Condition
- anemia present
- microcytic
- Mentzer index (MCV ÷ RBC) below 13
- ferritin ≥ 30 and transferrin saturation ≥ 20%
- RDW not raised
Supportive, not required
- target cells on the film
- high RBC count
What it reports
- Pattern that favors thalassemia trait: hemoglobin electrophoresis can confirm
Diagnostic boundary
- A screen, not a diagnosis.
Evidence
- EV-MENTZER-1973Mentzer WC Jr. Differentiation of iron deficiency from thalassaemia trait. Lancet. 1973;1(7808):882.Supports: Mentzer index below 13 favors thalassemia trait
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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