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CPE-011 · Etiologic patterns
AN-14: Hemolysis pattern
Hemolysis pattern. Evaluates anemia present.
Active rulePriority 2Anemia engine v1.0.0
Condition
- anemia present
- reticulocyte production index ≥ 2 or reticulocytes ≥ 2%
- at least two of: LDH above the upper limit, haptoglobin low, indirect bilirubin raised, spherocytes or schistocytes on the film
- OR a positive direct antiglobulin test with one marker
What it reports
- Pattern compatible with hemolysis
Recommended next steps (for physician review)
- Direct antiglobulin test, blood film and a search for the cause (autoimmune, mechanical, hereditary, drug, infection)
Diagnostic boundary
- Does not name the type.
Evidence
- EV-JAGER-2020Jäger U, Barcellini W, Broome CM, et al. Diagnosis and treatment of autoimmune hemolytic anemia in adults: Recommendations from the First International Consensus Meeting. Blood Rev. 2020;41:100648.Supports: Hemolysis markers and direct antiglobulin testing
Cases where this rule fires
Open a case to see this rule fire with real inputs, then change the values until it stops.
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