Start Free

Synthetic data only. Never enter patient information; nothing is sent or stored. For clinicians. Not FDA cleared.

CPE-010 · synthetic case PCOS-FX-18

Normal total testosterone and a low SHBG

A free androgen index of about 7.

Synthetic · no real patientAuthored by Biod · reviewed by Dr. AmaralPCOS engine v1.0.0

Purpose: A free androgen index of about 7.

Inputs the engine received

Cycles and clinical signs

Age
28 years
Years since menarche
15 years
Cycles per year
6

Laboratory and imaging

Total testosterone
38 ng/dL
SHBG
18 nmol/L
TSH
1.8 mIU/L
Prolactin
12 ng/mL
17-hydroxyprogesterone (early follicular, morning)
60 ng/dL

Cardiometabolic, sleep, mood and fertility

BMI
29 kg/m²
Months since last glycemic assessment
6 months
Depression and anxiety screening done
Yes

What the engine reports

Detected clinical pattern

Pattern Meeting the 2023 PCOS Criteria

Criteria are met and other causes are excluded. A pattern for physician review; the work-up of cardiometabolic risk, sleep, mood and fertility follows.

  • Criteria met: 2 of 3 criteria

Why this pattern was identified

  • Criteria. 2 of 3 criteria are met (irregular cycles; hyperandrogenism), and other causes have been excluded.

Calculations

Free androgen index
7.3

Total testosterone (nmol/L) ÷ SHBG × 100. Cutoffs vary by assay; above 5 is commonly used.

Recommended next steps

For physician consideration. Urgent review always comes first.

  1. 1Assess BMI and waist, blood pressure and a lipid profile; the metabolic engine applies the metabolic-syndrome criteria.
Evidence and rule trace · 5 rules

PC-17Free androgen index

Inputs: total testosterone 38 ng/dL · SHBG 18 nmol/L

Free androgen index 7.3.

PC-02Criterion: irregular cycles

Inputs: 6 cycles a year

Irregular cycles / ovulatory dysfunction.

PC-03Criterion: hyperandrogenism

Inputs: free androgen index 7.3

Clinical or biochemical hyperandrogenism.

PC-05PCOS criteria met

Inputs: 2 of 3 criteria · exclusions completed

Pattern meeting the 2023 international PCOS criteria.

PC-13Cardiometabolic assessment

Inputs: PCOS criteria met

Cardiometabolic assessment.

Evidence

  • EV-PCOS-2023 · Teede HJ, Tay CT, Laven JJE, et al. Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2023;108(10):2447-2469.
  • EV-ROTTERDAM-2004 · Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-47.
  • EV-ES-HIRSUTISM-2018 · Martin KA, Anderson RR, Chang RJ, et al. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(4):1233-1257.

Physician adjudication required. Clinical decision support for physician review. This output applies published criteria to the values entered. It does not diagnose, exclude other causes by itself, or choose contraception, ovulation induction or any treatment. Physician adjudication is required.

Change the values

The same engine, starting from this case. Change any value and watch the pattern and the rule trace react.

Criteria met (adults need 2 of 3)

  1. ✓ 0 of 3

    No criterion met

  2. ✓ 1 of 3

    Not enough

  3. ● 2 of 3

    Criteria met if causes are excluded

  4. ○ 3 of 3

    All three present

Cycles and clinical signs

6 or more (4 or more in some ethnicities).

Laboratory and imaging

25 ng/mL is assumed when empty.

Endovaginal ultrasound. Not used in adolescents.

Cardiometabolic, sleep, mood and fertility

Live result · computed in your browser

Detected clinical pattern

Pattern Meeting the 2023 PCOS Criteria

Criteria are met and other causes are excluded. A pattern for physician review; the work-up of cardiometabolic risk, sleep, mood and fertility follows.

  • Criteria met: 2 of 3 criteria

Why this pattern was identified

  • Criteria. 2 of 3 criteria are met (irregular cycles; hyperandrogenism), and other causes have been excluded.

Calculations

Free androgen index
7.3

Total testosterone (nmol/L) ÷ SHBG × 100. Cutoffs vary by assay; above 5 is commonly used.

Recommended next steps

For physician consideration. Urgent review always comes first.

  1. 1Assess BMI and waist, blood pressure and a lipid profile; the metabolic engine applies the metabolic-syndrome criteria.
Evidence and rule trace · 5 rules

PC-17Free androgen index

Inputs: total testosterone 38 ng/dL · SHBG 18 nmol/L

Free androgen index 7.3.

PC-02Criterion: irregular cycles

Inputs: 6 cycles a year

Irregular cycles / ovulatory dysfunction.

PC-03Criterion: hyperandrogenism

Inputs: free androgen index 7.3

Clinical or biochemical hyperandrogenism.

PC-05PCOS criteria met

Inputs: 2 of 3 criteria · exclusions completed

Pattern meeting the 2023 international PCOS criteria.

PC-13Cardiometabolic assessment

Inputs: PCOS criteria met

Cardiometabolic assessment.

Evidence

  • EV-PCOS-2023 · Teede HJ, Tay CT, Laven JJE, et al. Recommendations From the 2023 International Evidence-based Guideline for the Assessment and Management of Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2023;108(10):2447-2469.
  • EV-ROTTERDAM-2004 · Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-47.
  • EV-ES-HIRSUTISM-2018 · Martin KA, Anderson RR, Chang RJ, et al. Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2018;103(4):1233-1257.

Physician adjudication required. Clinical decision support for physician review. This output applies published criteria to the values entered. It does not diagnose, exclude other causes by itself, or choose contraception, ovulation induction or any treatment. Physician adjudication is required.

More pcos cases

PCOS-FX-01

Irregular cycles and hirsutism, exclusions complete

A 26-year-old with 8 cycles a year and an mFG of 9.

PCOS-FX-02

Irregular cycles and polycystic ovaries

No hyperandrogenism, 22 follicles per ovary.

PCOS-FX-03

Hyperandrogenism and polycystic ovaries with regular cycles

Ovulatory phenotype.

PCOS-FX-04

Irregular cycles only

One criterion is not enough.

PCOS-FX-05

Criteria met, no exclusion tests

TSH, prolactin and 17-OHP missing.

PCOS-FX-06

Prolactin 68 ng/mL

Another cause of oligomenorrhea.

All pcos cases

Try Biod in your practice

The Clinical Intelligence Layer — transforming fragmented clinical information into structured intelligence for clinician review and action.

Start Free for 3 Months (opens in a new tab)Send us a message

Contact Biod