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CPE-011 · Etiologic patterns
AN-17: Cytopenias: marrow involvement possible
Cytopenias: marrow involvement possible. Evaluates hemoglobin below 10 g/dL with WBC below 3.5 ×10³/µL and platelets below 100 ×10³/µL (pancytopenia).
Condition
- hemoglobin < 10 g/dL with WBC < 3.5 ×10³/µL and platelets < 100 ×10³/µL (pancytopenia)
- OR anemia with platelets < 50 ×10³/µL
What it reports
- Pattern that raises marrow failure, infiltration or severe megaloblastic anemia
Diagnostic boundary
- Needs hematology evaluation.
Evidence
- EV-TEFFERI-2003Tefferi A. Anemia in adults: a contemporary approach to diagnosis. Mayo Clin Proc. 2003;78(10):1274-1280.Supports: Classification by MCV and reticulocyte response; first-line studies
- EV-DEVALIA-2014Devalia V, Hamilton MS, Molloy AM; British Committee for Standards in Haematology. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. Br J Haematol. 2014;166(4):496-513.Supports: Megaloblastic anemia and its evaluation
Cases where this rule fires
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