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CPE-011 · Etiologic patterns
AN-18: Macrocytosis from non-vitamin causes
Macrocytosis from non-vitamin causes. Evaluates anemia present.
Active rulePriority 5Anemia engine v1.0.0
Condition
- anemia present
- macrocytic
- alcohol use disorder OR liver disease OR hypothyroidism (TSH raised) OR macrocytosis-causing drug OR age 60 and over with cytopenias
What it reports
- Non-vitamin causes of macrocytosis are present: alcohol, liver disease, hypothyroidism, drugs (hydroxyurea, methotrexate, zidovudine), myelodysplasia
Diagnostic boundary
- Can coexist with a vitamin deficiency.
Evidence
- EV-TEFFERI-2003Tefferi A. Anemia in adults: a contemporary approach to diagnosis. Mayo Clin Proc. 2003;78(10):1274-1280.Supports: Classification by MCV and reticulocyte response; first-line studies
Cases where this rule fires
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